Overview:
InitiallyshowntoinhibitSir2p(theyeastSirt1homolog)andcreateaconditionalphenocopyofasir2deletionmutantinS.cerevisiae1.Cellsgrowninthepresenceofthedrughavesilencingdefectsattelomeres,silentmating-typelociandtheribosomalDNA1.InhibitsallclassIIIHDACs(sirtuins)andalleviatesgenesilencinginFragileXmentalretardationsyndrome2.Reversesischemicpreconditioning-inducedcardioprotectioninamousemodel3.
References:
1.ABedalovetal.Proc.Natl.Acad.Sci.USA200198:151132.RBiacsietal.PLoSGenet.20084(3):e10000173.SMNadtochiyetal.Cardiovasc.Res.201189:643
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

