Overview:
STK3, also known as MST2, encodes a protein of 491-amino acid which contains an N-terminal catalytic domain characteristic of STKs (1). STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall. RAF1 has been shown to counteract apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). STK3 is a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (2). STK3 activation presumably allows cells to resist unfavorable environmental conditions.
Gene Aliases:
KRS1; MST2; FLJ90748
Genbank Number:
BC010640
References:
1.Creasy, C L. et al: Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306, 1995.2.Lee, K K. et al: MST, a physiological caspase substrate, higly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276: 19276-19285, 2001.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

