BiologicalActivity
Cell-permeableactivatorofadenylylcyclase.Hypotensiveandvasodilatoryagent.Inducesneuronaldifferentiationinstemcellsandinseveralneuroblastoma.Usedtoreprogrammouseembryonicfibroblaststoinducedpluripotentstemcellsincombinationwiththreeothersmallmolecules(Cat.Nos.3742,4423and4703).AlsoavailableaspartofthePKATocriset™.
CompoundLibraries
ForskolinisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolboxandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 410.51 |
| Formula | C22H34O7 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 66575-29-9 |
| PubChemID | 47936 |
| InChIKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| Smiles | C=C[C@](C3)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@](O)2C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.26 | 25 | |
| ethanol | 4.11 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight410.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.18mL | 24.36mL |
| 5mM | 0.49mL | 2.44mL | 4.87mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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