Tocris厂家直采，平行进口 Tocris Bioscience中国采购,Tocris/GSK J1/4593/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/GSK J1/4593/50/50 mg

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Tocris

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4593/50

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4000-520-616

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Description:PotentJMJD3/UTXinhibitor

ChemicalName:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitoroftheH3K27histonedemethylasesJMJD3(KDM6B)andUTX(KDM6A)(IC₅₀valuesare28and53nMrespectively).AlsoinhibitsKDM5B,KDM5CandKDM5A(IC₅₀valuesare170,550and6,800nMrespectively).Exhibitsnoactivityagainstapanelofotherhistonedemethylases(IC₅₀>20μM),anddisplaysnosignificantinhibitoryactivityagainst100proteinkinasesataconcentrationof30μM.Ethylesterderivativealsoavailable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheGSKJ1probesummaryontheSGCwebsite.

CompoundLibraries

GSKJ1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	389.45
Formula	C₂₂H₂₃N₅O₂
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	1373422-53-7
PubChemID	56963315
InChIKey	AVZCPICCWKMZDT-UHFFFAOYSA-N
Smiles	O=C(CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	38.94	100
	ethanol	38.94	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight389.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.57mL	12.84mL	25.68mL
5mM	0.51mL	2.57mL	5.14mL
10mM	0.26mL	1.28mL	2.57mL
50mM	0.05mL	0.26mL	0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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