Tocris一级代理 Tocris GPCR ligands,Tocris/MK 886/1311/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/MK 886/1311/50/50 mg

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Tocris

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1311/50

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Description:Inhibitorof5-lipoxygenase-activatingprotein(FLAP)

AlternativeNames:L-663,536

ChemicalName:1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Aninhibitorofleukotrienebiosynthesis(IC₅₀=3nMinhumanpolymorphonuclearleukocytes).Actsbyinhibiting5-lipoxygenase-activatingprotein(FLAP)(IC₅₀=30nMforinhibitionof[¹²⁵I]-L-691,678photoaffinitylabelling).AlsomoderatelypotentPPARαantagoNIST(IC₅₀=0.5-1μM).Orallyactiveinvivo.

TechnicalData

M.Wt	472.08
Formula	C₂₇H₃₄ClNO₂S
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	118414-82-7
PubChemID	3651377
InChIKey	QAOAOVKBIIKRNL-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3CN(C(CC(C)(C(O)=O)C)=C2SC(C)(C)C)C1=C2C=C(C(C)C)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	47.21	100
	ethanol	2.36	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight472.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.12mL	10.59mL	21.18mL
5mM	0.42mL	2.12mL	4.24mL
10mM	0.21mL	1.06mL	2.12mL
50mM	0.04mL	0.21mL	0.42mL

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