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Tocris/NKH 477/1603/50/50 mg
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Tocris/NKH 477/1603/50/50 mg
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Tocris
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1603/50
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Description:Water-solubleadenylylcyclaseactivator
AlternativeNames:Colforsindapropatehydrochloride,6-(3-dimethylaminopropionyl)forskolinhydrochloride
ChemicalName:N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Water-solubleanalogofforskolin(Cat.No.1099)thatisapotentactivatorofadenylylcyclase;showssomeselectivityforcardiac(typeV)adenylylcyclase.Stimulatesbronchodilation(EC50=32.6nM)andisanorallyactivepotentpositivechronotropeandhypotensiveagentinvivo.AlsoavailableaspartofthePKATocriset™.

TechnicalData

M.Wt546.1
FormulaC27H43NO8.HCl
StorageDesiccateat+4°C
Purity≥98%(HPLC)
CASNumber138605-00-2
PubChemID444028
InChIKeyVIRRLEDAYYYTOD-YHEOSNBFSA-N
SmilesO=C(CCN(C)C)O[C@H]2[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@]3(O)[C@@](O[C@](C=C)(C)CC3=O)(C)[C@H]2OC(C)=O.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO54.61100
ethanol8.1915
water21.8440

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight546.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.83mL9.16mL18.31mL
5mM0.37mL1.83mL3.66mL
10mM0.18mL0.92mL1.83mL
50mM0.04mL0.18mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet