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Description:LSD1inhibitor
ChemicalName:1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanonedihydrochloride
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentlysinespecificdemethylase1(LSD1)inhibitor(IC50=70nM).ExhibitsselectivityforLSD1overMAO-AandMAO-B(IC50valuesare0.51and2.79μMforMAO-AandMAO-B,respectively).Impairslong-term,butnotshort-termmemoryinmice.BrainpenetrantfollowingsystemicadmiNISTration.
CompoundLibraries
RN1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 452.42 |
Formula | C23H29N3O2.2HCl |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 1781835-13-9 |
PubChemID | 90488995 |
InChIKey | WMHAFZOOUBPQRX-VSIGASKDSA-N |
Smiles | O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.05 | 20mMwithgentlewarming | |
water | 9.05 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight452.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.21mL | 11.05mL | 22.1mL |
5mM | 0.44mL | 2.21mL | 4.42mL |
10mM | 0.22mL | 1.11mL | 2.21mL |
50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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