BiologicalActivity
PotentMTH1inhibitor(Kd=49nM).InhibitsRas-inducedmalignanttransformationandincreasesα-actinpromoter-drivenCATactivityinRas-transformedcells.HasnoeffectonRas-inducedERKandJNKactivation.InhibitsRas-inducedmembranerufflinginREF-52fibroblastsandblocksanchorage-independentgrowthofRas-transformedtumorcelllines.AlsoinducesDNAdamageinSW480coloncancercells.
CompoundLibraries
SCH51344isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 316.35 |
| Formula | C16H20N4O3 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 171927-40-5 |
| PubChemID | 9995890 |
| InChIKey | YWEGXZZAORIRQR-UHFFFAOYSA-N |
| Smiles | CC1=NN=C(N3)C1=C(NCCOCCO)C2=C3C=CC(OC)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 | |
| ethanol | 3.16 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.81mL | 31.61mL |
| 5mM | 0.63mL | 3.16mL | 6.32mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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