Background
Highlyselectiveinhibitorofphosphatidylinositol3-kinase(IC50=0.31,0.73,1.06and6.60µMforPI3-Kβ,PI3-Kα,PI3-KδandPI3-Kγrespectively)1.Inhibitsautophagyinrathepatocytes(IC50=10µM)2.AnextremelyusefultoolfordeterminingtheroleofPI3-Kincellularsignaling3.Cellpermeable.MorestableinsolutionthanWortmannin,andalsoblocksautophagosomeformation.
Application
InhibitsAutophagy
ProductInformation
Purity: >98%byTLC
MW: 307.4
Formula: C19H17NO3
CASNo. 154447-36-6
PhysicalState: Lyophilizedwhitepowder
Amount: 5mg,25mg
Solubility: 20mg/mLinwarmDMSO;8mg/mLinwarmethanol
Storage: Storedesiccatedassuppliedat-20°Cforupto3years.Storesolutionsat-20°Cforupto3months.
References
1.CJVlahosetal.J.Biol.Chem.1994269:5241
2.EFBlomaartetal.Eur.J.Biochem.1997243:240
3.SChasSEROt-Golazetal.J.NeuRochem.199870:2347
Documents
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

