Background
Semisyntheticalkaloidalanticanceragent.InducescellcyclearrestatG2/Mphasebyinhibitingmitoticspindleformation1.Inhibitsnormalmicrotubuleassemblyandinducesaberranttubulinpolymerization1.Inducesapoptosisinavarietyofcelllines2.Inhibitsautophagosomematuration3.Inhibitspalmitoylationoftubulin4.VinblastinesulfateinhibitsmicrotubuleformationandsuppressesnAChRactivitywithIC50of8.9μMinacell-freeassay,usedtotreatcertainkindsofcancer.
Application
Autophagyinhibitor:inhibitsautophagosomematuration
ProductInformation
Purity: 98%byTLC
MW: 909.1
Formula: C46H58N4O9.H2SO4
CASNo. 143-67-9
PhysicalState: Lyophilizedwhitecrystallinepowder
Amount: 5mg,25mg
Solubility: 25mg/mLinDMSO;50mg/mLinwater
Storage: Storedesiccatedassuppliedat-20°Cforupto1year.Storesolutionsat-20°Cforupto1month.
References
1.EHamelMed.Res.Rev.199616:207
2.KTsukidateetal.Am.J.Pathol.1993143:918
3.CPSatorietal.Anal.Chem.201385:11391
4.JMCaronandMHerwoodChemotherapy200753:51
Documents
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

