Background
BindstotheN-terminaldomainofvalosin-containingprotein(VCP),anessentialproteinforautophagosomematuration.XanthohumolinhibitsthefunctionofVCPtherebyimpairingautophagosomematurationresultinginaccumulationofthemicrotubule-associatedprotein1lightchain3-II(LC3-II)1.Impairsprostatecancercellgrowthandproliferation2.Suppressesgrowthofpancreaticcancercellsviadown-regulationofNotch1signaling3.Cellpermeable.Xanthohumol,aprenylatedchalconefromhop,inhibitsCOX-1andCOX-2activityandshowschemopreventiveeffects.
Application
Impairsautophagosomematuration
ProductInformation
Purity: >98%byTLC
MW: 354.4
Formula: C21H22O5
CASNo. 6754-58-1
PhysicalState: Lyophilizedyellowpowder
Amount: 5mg,25mg
Solubility: 35mg/mLinDMSOorethanol
Storage: Storedesiccatedassuppliedat-20°Cforupto3years.Storesolutionsat-20°Cforupto1month.
References
1.YSasazawaetal.ACSChem.Biol.20127:892
2.RVeneetal.Mol.Med.201218:1292
3.SKunnimalaiyaanetal.Mol.CancerTher.201514:1395
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

