Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.
Application
Binds cereblon, inhibiting ubiquitin ligase activity; alsoTNF-a synthesis inhibitor
Product Information
Purity: >98%
MW: 258.24
Formula: C13H10N2O4
CAS Number: 50-35-1
Physical State: Lyophilized white solid
Quantity: 1g; 5g
Solubility: 6 mg/mL in DMSO
Storage: 2-8°C
Documents
Reference
1. Boireau et al (1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett. 234 123 PMID: 9364513
2. Kanbayashi et al (1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881 PMID: 8905685
3. Makonkawkeyoon et al (1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 90 5974 PMID: 8327469
4. Zhang et al (2008) Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 27 60 PMID: 18983651
5. Sampaio et al (1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699 PMID: 1997652
6. Merck Index 12 9390
7. Ito et al (2010) Identification of a primary target of thalidomide teratogenicity. Science 327 1345 PMID: 20223979
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
那糖酵解中依赖NAD的酶不是要在线粒体内反应？
蛋白酶分布广泛,主要存在于人和动物消化道中，而消化道通过口与肛门与外界相通，属于外环境或外界环境
（溶菌酶、凝血酶原等）分布在内环境
（消化）酶分布在消化道
