Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.
Application
Functionalized cereblon ligand for PROTACs
Product Information
Purity: >98%
MW: 332.26
Formula: C15H12N2O7
CAS Number 1061605-21-7
Physical State: Lyophilized off white solid
Quantity: 5mg; 10mg; 25mg
Solubility: 30 mg/mL in DMSO
Storage: Store at room temperature.
Documents
References
1. Lohbeck and Miller (2016) Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

