Derivativeof Thalidomide (Cat.No.PC-1006),commonlyusedasaprecursortoPROTACsthathijackcereblonastheE3ubiquitinligasecomponent.Suppliedwithacarboxylicacidfunctionalhandleatapositionknownnottosignificantlyaffectbindingtocereblon,forreadyconjugationtoalinker/targetproteinligand.
Application
FunctionalizedcereblonligandforPROTACs
ProductInformation
Purity: >98%
MW: 332.26
Formula: C15H12N2O7
CASNumber 1061605-21-7
PhysicalState: Lyophilizedoffwhitesolid
Quantity: 5mg;10mg;25mg
Solubility: 30mg/mLinDMSO
Storage: Storeatroomtemperature.
Documents
References
1. LohbeckandMiller (2016)Practicalsynthesisofaphthalimide-basedcereblonligandtoenablePROTACdevelopment.Bioorg.Med.Chem.Lett. 26 5260PMID: 27687673
ebiomall.com
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

