Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Application
Functionalized cereblon ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
Product Information
Purity: >99%
MW: 620.53
Formula: C25H31F3N4O11
CAS No. 1957236-21-3
Physical State: Lyophilized white solid
Quantity: 5mg; 10mg; 25mg
Solubility: 50 mg/mL in DMSO; 50 mg/mL in water
Storage: Store at -20C.
References
1. Winter et al (2015) Functionalized Cereblon ligand for PROTACs; incorporates an E3 ligase ligand and a linker used in PROTAC technology. Science 348 1376 PMID: 25999370
2. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825
Documents
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

