SENP1 is a SUMO isopeptidase that plays a critical role in the development of prostate cancer. SENP1 is overexpressed in prostate cancer samples. Overexpression of SENP1 in the prostate of mice leads to the development of prostatic intraepithelial neoplasia at an early stage. Consistent with the role of SENP1 in prostate cancer, it has demonstrated that overexpression of SENP1 enhances androgen-receptor mediated transcription. Inactivation of SENP1 in mice by retroviral insertion mutation is embryonic lethal (e12.5-e14.5) and leads to an increase in the steady state levels of SUMOylated forms of a number of proteins. Depletion of SENP1 levels in PC3 cells by RNAi leads to a decrease in cyclin D1 expression.
Info
| State | Liquid |
| Molecular Weight | 28 kDa |
| Source | Chicken |
| Storage | Store at -20°C |
| Family | Desumoylase |
Applications
- Recommended antibody dilutions for Western Blot: robust detection of 100 ng of recombinant protein at 5 µg/mL
Documents
ebiomall.com
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

