UBE2S (also known as E2-24K or E2-EPF) is an E2 conjugating enzyme that is involved in the ubiquitylation of target substrates along with E1 and E3 enzymes. It has been implicated in the ubiqutylation of anaphase-promoting complex (APC/C), promoting the elongation of K11-linked polyubiquitin chains on this substrate, after initial ubiquitylation by either UBE2C or UBE2D1. This polyubiquitin chain elongation enhances degradation of APC/C by the proteasome. UBE2S also targets von Hippel-Lindau (VHL) for proteasome degradation, resulting in the stabilization of HIF-1a.
Info
| Amount | 3 nmol |
| State | Liquid |
| Molecular Weight | 23,845.3 Da |
| Source | Human Recombinant |
| Fusion Tag | None |
| Accession Number | Q16763 |
| Alternate Names | E2EPF, E2-EPF, EPF5 |
| Storage | -80°C, avoid freeze/thaw cycles |
| Stability | 1 year under recommended storage conditions |
| Recommended Use | Enzyme concentration of 100 nM – 1 mM is recommended for in vitro conjugation. |
Applications
- Identify cognate E2/E3 pairs
- Characterize upregulation/downregulation of E2 enzymes
- Build poly-ubiquitin chains
- Characterize ubiquitin chain specificity of E2 enzymes
- Analyze expression of E2 enzymes
Benefits
- Untagged (native) E2 conjugation enzyme
Documents
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

