UBE2C (also known as Ubc10) is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2C interacts with the Anaphase Promoting Complex (APC) and as a member of this complex functions to ubiquitylate substrates and target these substrates, which include several cyclins, for degradation. As such UBE2C plays a critical role in cell cycle progression, and has recently been shown to play a key role in tumorigenesis.
Info
| Amount | 3 nmol |
| State | Liquid |
| Molecular Weight | 19,652.3 Da |
| Source | Human Recombinant |
| Fusion Tag | None |
| Accession Number | O00762 |
| Alternate Names | Ubc10, Ubiquitin conjugating enzyme E2 C |
| Storage | -80°C, avoid freeze/thaw cycles |
| Stability | 1 year under recommended storage conditions |
| Recommended Use | Enzyme concentration of 100 nM – 1 mM is recommended for in vitro conjugation. |
Applications
- Identify cognate E2/E3 pairs
- Characterize upregulation/downregulation of E2 enzymes
- Build poly-ubiquitin chains
- Characterize ubiquitin chain specificity of E2 enzymes
- Analyze expression of E2 enzymes
Benefits
- Untagged (native) E2 conjugation enzyme
Documents
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

