SENP1isaSUMOisopeptidasethatplaysacriticalroleinthedevelopmentofprostatecancer.SENP1isoverexpressedinprostatecancersamplesandtransgenicoverexpressionofSENP1intheprostateofmiceleadstothedevelopmentofprostaticintraepithelialneoplasiaatanearlyage. Consistentwiththemodelstatedabove,investigatorshavedemonstratedthatoverexpressionofSENP1enhancesandrogen-receptormediatedtranscription.InactivationofSENP1inmicebyretroviralinsertionalmutationisembryoniclethal(e12.5-e14.5)andleadstoanincreaseinthesteady-statelevelsofSUMOylatedformsofanumberofproteins. DepletionofSENP1levelsinPC3cellsbyRNAileadstoadecreaseincyclinD1expression.ReinforcingthepotentialroleSENP1mayplayinprostatecanceristheobservationthatSENP1isoverexpressedinmanyprostatecancersamples.
Info
Amount | 25µg |
State | Liquid |
MW | 28kDa |
Source | HumanRecombinant |
FusionTag | His6 |
Storage | Storeat-80ºC,avoidingrepeatedfreeze-thawcycles. |
AlternativeNames | Sentrin/SUMO-specificproteaseSENP1,Sentrin-specificprotease1 |
ExpressionHost | E.coli |
RecommendedSubstrate | hSUMO1-AMC(Cat.#SI420)&hSUMO2-AMC(Cat.#SI520),hSUMO2-Rhodamine(Cat.#SI530) |
GeneID |
Applications
- ThisenzymeisactiveintheSUMO3-CHOPassay.
Documents
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

