中国Tocris公司 Tocris Bioscience中国试剂购买网站,Tocris/AMG PERK 44/5517/50/50 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AMG PERK 44/5517/50/50 mg

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Tocris

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5517/50

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4000-520-616

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Description:PotentandselectivePERKinhibitor;orallybioavailable

ChemicalName:4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-onehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectivePERKinhibitor(IC₅₀=6nM).Exhibits>160-foldselectivityforPERKoverB-RafandGCN2,aswellasapanelof387otherkinases.Orallybioavailable.

LicensingInformation

Bypermissionoftheauthors

CompoundLibraries

AMGPERK44isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	561.07
Formula	C₃₄H₂₈N₄O₂.HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	121513867
InChIKey	RNAKBTDDCHJCMT-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=C(C3=C(N)C(C(C4=C(C5=CC=CC=C5)N(C)N(C6=CC=CC=C6)C4=O)=O)=CC=C3C)C=C1C=C2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	52.46	100
	water	52.46	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight561.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.78mL	8.91mL	17.82mL
5mM	0.36mL	1.78mL	3.56mL
10mM	0.18mL	0.89mL	1.78mL
50mM	0.04mL	0.18mL	0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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