BiologicalActivity
Akt/proteinkinaseB(PKB)inhibitor.BindsthepleckstrinhomologydomainofAktandblocksAktmembranetranslocation.InhibitsEGF-inducedkinaseactivityofAkt1,Akt2andAkt3.InducescellgrowtharrestandapoptosisinhumancancercellsexpressingconstitutivelyactiveAkt.Displaysantitumoractivityinvitroandinvivo.
CompoundLibraries
API-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 337.29 |
| Formula | C13H15N5O6 |
| Storage | StoreatRT |
| Purity | ≥96%(HPLC) |
| CASNumber | 36707-00-3 |
| PubChemID | 24773090 |
| InChIKey | SPBWHPXCWJLQRU-FITJORAGSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CN=C3N)=C3C(C(C(N)=O)=C2)=O)[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight337.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.96mL | 14.82mL | 29.65mL |
| 5mM | 0.59mL | 2.96mL | 5.93mL |
| 10mM | 0.3mL | 1.48mL | 2.96mL |
| 50mM | 0.06mL | 0.3mL | 0.59mL |
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