Tocris经销商/代理商 Tocris Bioscience现货代理,Tocris/APY 29/4865/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/APY 29/4865/10/10 mg

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Tocris

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4865/10

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4000-520-616

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Description:InhibitsIRE1αautophosphorylation;activatesIRE1αendoribonucleaseactivity

ChemicalName:N²-1H-Benzimidazol-6-yl-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AllostericmodulatorofIRE1α.InhibitsIRE1αautophosphorylation(IC₅₀=280nM)andactivatesIRE1αribonucleaseactivity.

CompoundLibraries

APY29isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	332.36
Formula	C₁₇H₁₆N₈
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1216665-49-4
PubChemID	42627755
InChIKey	WJNBSTLIALIIEW-UHFFFAOYSA-N
Smiles	C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	16.62	50
	DMSO	33.24	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight332.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.01mL	15.04mL	30.09mL
5mM	0.6mL	3.01mL	6.02mL
10mM	0.3mL	1.5mL	3.01mL
50mM	0.06mL	0.3mL	0.6mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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