Tocris厂家直采，平行进口中国Tocris Bioscience公司,Tocris/AR-A 014418/3966/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AR-A 014418/3966/10/10 mg

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Tocris

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3966/10

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4000-520-616

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Description:SelectiveGSK-3inhibitor

ChemicalName:N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveglycogensynthasekinase3(GSK-3)inhibitor(IC₅₀=104nM).ExhibitsspecificityforGSK-3overcdk2andcdk5(IC₅₀valuesare>100μM)andover26otherkinases.Inhibitsβ-amyloid-mediatedneurodegenerationinhippocampalslices.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

AR-A014418isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	308.31
Formula	C₁₂H₁₂N₄O₄S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	487021-52-3
PubChemID	448014
InChIKey	YAEMHJKFIIIULI-UHFFFAOYSA-N
Smiles	O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	30.83	100
	ethanol	1.54	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight308.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.24mL	16.22mL	32.43mL
5mM	0.65mL	3.24mL	6.49mL
10mM	0.32mL	1.62mL	3.24mL
50mM	0.06mL	0.32mL	0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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