BiologicalActivity
Selectiveneuronalnitrogenoxidesynthase(nNOS)inhibitor(IC50valuesare1and17μMfornNOSandendothelialNOSrespectively).Reducesischemiccelldamageaftermiddlecerebralartery(MCA)occlusioninrats.DisplaysasynergisticneuroprotectiveeffectwhencombinedwitheitheranNMDAorAMPAreceptorantagoNIST.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
TechnicalData
| M.Wt | 442.83 |
| Formula | C20H20ClN3S.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 866914-87-6 |
| PubChemID | 9824646 |
| InChIKey | SOXBYIKSUDXMIE-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.28 | 100 | |
| water | 22.14 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight442.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.29mL | 22.58mL |
| 5mM | 0.45mL | 2.26mL | 4.52mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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