BiologicalActivity
FAAH-likeanandamidetransporter(FLAT)inhibitor(IC50=1.8μM);cytosolicvariantofFAAH-1thatbindsanandamide.Attenuatesanandamideinternalizationanddeactivationinvitroandinvivorespectively.ExhibitsanalgesiceffectsinrodentmodelsofCB1-mediatednociceptiveandinflammatorypain.
TechnicalData
| M.Wt | 432.47 |
| Formula | C27H20N4O2 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 488793-85-7 |
| PubChemID | 24802717 |
| InChIKey | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 | |
| ethanol | 8.65 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight432.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.56mL | 23.12mL |
| 5mM | 0.46mL | 2.31mL | 4.62mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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