BiologicalActivity
Potentandselectiveinterleukin-1receptor-associatedkinase4(IRAK4)inhibitor(IC50=21nM).Displays30-foldselectivityforIRAK4overIRAK1.InhibitsLPS-inducedTNF-αandIL-6productioninPBMCsinvitro.Renoprotectiveandanti-inflammatoryinarodentmodelofchronickidneydisease.
CompoundLibraries
AS2444697isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 432.86 |
| Formula | C19H20N6O4.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1287665-60-4 |
| PubChemID | 118719434 |
| InChIKey | FGNHLIIFEDYNFZ-UHFFFAOYSA-N |
| Smiles | O=C(N)C2=NN(C=C2NC(C3=COC(C4=CC=NC(C)=C4)=N3)=O)C1CCOCC1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.29 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight432.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.55mL | 23.1mL |
| 5mM | 0.46mL | 2.31mL | 4.62mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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