BiologicalActivity
PotentandselectiveinhibitorofPI3-kinaseγ(PI3-Kγ)(IC50=8nM).Displays30-foldselectivityoverPI3-KδandPI3-Kβand7.5-foldselectivityoverPI3-Kα.Suppressestheprogressionofjointinflammationanddamageinbothlymphocyte-independentandlymphocyte-dependentmousemodelsofrheumatoidarthritis.OrallyactiveandATP-competitive.
TechnicalData
| M.Wt | 257.27 |
| Formula | C12H7N3O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 648450-29-7 |
| PubChemID | 5289247 |
| InChIKey | SQWZFLMPDUSYGV-POHAHGRESA-N |
| Smiles | O=C(/C(S3)=C/C(C=C2)=CC1=C2N=CC=N1)NC3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.26 | 1mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight257.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.89mL | 19.43mL | 38.87mL |
| 5mM | 0.78mL | 3.89mL | 7.77mL |
| 10mM | 0.39mL | 1.94mL | 3.89mL |
| 50mM | 0.08mL | 0.39mL | 0.78mL |
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