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Description:SelectiveinhibitorofPTPMT1
ChemicalName:N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamidedihydrochloride
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selectiveinhibitorofproteintyrosinephosphataseslocalizedtomitochondrion1(PTPMT1)(IC50=1.08μMinvitro).Stimulatesincreasedinsulinsecretionbyβ-cellsinratpancreaticislets.DisplaysantitcancerpropertiesinFaDucells.Alsopreservesfunctionalhematopoieticstemcellsexvivo.
TechnicalData
| M.Wt | 581.71 |
| Formula | C26H56N10.2HCl |
| Storage | Desiccateat-20°C |
| CASNumber | 1715-30-6 |
| PubChemID | 102678 |
| InChIKey | BRJJFBHTDVWTCJ-UHFFFAOYSA-N |
| Smiles | N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.17 | 100 | |
| ethanol | 58.17 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight581.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.72mL | 8.6mL | 17.19mL |
| 5mM | 0.34mL | 1.72mL | 3.44mL |
| 10mM | 0.17mL | 0.86mL | 1.72mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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ProductDatasheets
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