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Description:ADAM-17(TACE)andMMPinhibitor
AlternativeNames:TNF-αprocessinginhibitor-0
ChemicalName:N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
ADAM-17(TACE)andMMPinhibitor;attenuatesTNF-αprocessing.ActsinconcertwithGM6001(Cat.No.2983)toinhibitChlamydiatrachomatisgrowth.
TechnicalData
| M.Wt | 456.54 |
| Formula | C24H32N4O5 |
| Storage | Storeat-20°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 163958-73-4 |
| PubChemID | 3035404 |
| InChIKey | CRCPLBFLOSEABN-VBSNWNEZSA-N |
| Smiles | ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto10mg/mlinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight456.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.19mL | 10.95mL | 21.9mL |
| 5mM | 0.44mL | 2.19mL | 4.38mL |
| 10mM | 0.22mL | 1.1mL | 2.19mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
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ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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