BiologicalActivity
Apoptosisactivator;promotesthecytochromec-dependentoligomerizationofApaf-1intothematureapoptosome.Increasesprocaspase-9processingandsubsequentcaspase-3activation.Inducesapoptosisintumorcells(IC50=4-9μMforleukemiacells)withweakornoeffectonnormalcelllinesorthosedefective/deficientinApaf-1,caspase-9orcaspase-3activity(IC50>40μM).
CompoundLibraries
ApoptosisActivator2isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 306.14 |
| Formula | C15H9Cl2NO2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 79183-19-0 |
| PubChemID | 1901244 |
| InChIKey | KGRJPLRFGLMQMV-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.61 | 100 | |
| ethanol | 1.53 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight306.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.27mL | 16.33mL | 32.66mL |
| 5mM | 0.65mL | 3.27mL | 6.53mL |
| 10mM | 0.33mL | 1.63mL | 3.27mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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