BiologicalActivity
Potentinhibitorofthrombinmediatedfibrinogencleavage(Ki=19nM).Competitiveinhibitorofthrombin-inducedplateletactivationandclotting.Showntoexhibitantithromboticactivityinanimalmodels.
CompoundLibraries
ArgatrobanisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 508.63 |
| Formula | C23H36N6O5S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 74863-84-6 |
| PubChemID | 6604954 |
| InChIKey | CQTDZUSQSTUZDA-UHFFFAOYSA-M |
| Smiles | O=C(N1[C@@H]([C@@](O)=O)C[C@H](C)CC1)[C@@H](NS(C2=CC=CC3=C2NCC(C)C3)(=O)=O)CCCNC(N)=N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 5.09 | 10 | |
| DMSO | 50.86 | 100 | |
| ethanol | 2.54 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight508.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.97mL | 9.83mL | 19.66mL |
| 5mM | 0.39mL | 1.97mL | 3.93mL |
| 10mM | 0.2mL | 0.98mL | 1.97mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
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