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Tocris/CP 471474/3780/10/10 mg

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Tocris

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3780/10

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4000-520-616

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Description:BroadspectrumMMPinhibitor

ChemicalName:2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

BroadspectrumMMPinhibitor(IC₅₀valuesare0.7,0.9,13,16and1170nMforMMP-2,MMP-13,MMP-9,MMP-3andMMP-1respectively).Attenuatesearlyleftventriculardilationafterexperimentalmyocardialinfarctioninmice.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

CP471474isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	368.38
Formula	C₁₆H₁₇FN₂O₅S
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	210755-45-6
PubChemID	9907286
InChIKey	QCOQJYRPDUMCNP-UHFFFAOYSA-N
Smiles	FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	36.84	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight368.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.71mL	13.57mL	27.15mL
5mM	0.54mL	2.71mL	5.43mL
10mM	0.27mL	1.36mL	2.71mL
50mM	0.05mL	0.27mL	0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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