BiologicalActivity
Dipeptidaseinhibitor(LTDase,leukotrieneD4hydrolase,dehydropeptidaseI)thatdisplaysaKivalueof0.11μM.InhibitsmetabolismofLTD4toLTE4andthehydrolysisofβ-lactamantibiotics.Nephroprotective;reducestoxicaccumulationofcyclosporinAinkidneyproximaltubuleepithelialcells.
TechnicalData
| M.Wt | 380.43 |
| Formula | C16H25N2NaO5S |
| Storage | Desiccateat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 81129-83-1 |
| PubChemID | 23702512 |
| InChIKey | QXPBTTUOVWMPJN-VQAYNFQASA-M |
| Smiles | [Na+].N[C@H](CSCCCCC=C(/NC(=O)[C@H]1CC1(C)C)C(O)=O)C([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.8 | 10 | |
| water | 38.04 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight380.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.63mL | 13.14mL | 26.29mL |
| 5mM | 0.53mL | 2.63mL | 5.26mL |
| 10mM | 0.26mL | 1.31mL | 2.63mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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