BiologicalActivity
PotentanticanceragentthatblocksDNAsynthesis.Inducesapoptosisviap53-dependentand-independentmechanisms.InhibitsX-linkedinhibitorofapoptosisprotein(XIAP)expressionandactivatescaspase-3.Incertaingliomacelllines,sensitizescellstoTNF-α-inducedapoptosis.
TechnicalData
| M.Wt | 300.05 |
| Formula | Cl2H6N2Pt |
| Storage | StoreatRT |
| CASNumber | 15663-27-1 |
| PubChemID | 84691 |
| InChIKey | LXZZYRPGZAFOLE-UHFFFAOYSA-L |
| Smiles | N.N.[Cl-].[Cl-].[Pt++] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.5 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight300.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.33mL | 16.66mL | 33.33mL |
| 5mM | 0.67mL | 3.33mL | 6.67mL |
| 10mM | 0.33mL | 1.67mL | 3.33mL |
| 50mM | 0.07mL | 0.33mL | 0.67mL |
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