BiologicalActivity
Inhibitorofγ-secretase;causesareductioninAβ40andAβ42levelsinhumanprimaryneuronalcultures(IC50valuesare115and200nMfortotalAβandAβ42respectively)andinbrainextract,cerebrospinalfluidandplasmainvivo.DoesnotaffectAPPαandAPPβlevels.BlocksNotchsignalinginhybridhuman-mousefetalthymusorganculture(FTOC).ActivitycausesESCstocommittoneuronaldifferentiation.
CompoundLibraries
DAPTisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 432.46 |
| Formula | C23H26F2N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 208255-80-5 |
| PubChemID | 5311272 |
| InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| Smiles | CC(C)(C)OC([C@H]([C@]2=CC=CC=C2)NC([C@H](C)NC(CC1=CC(F)=CC(F)=C1)=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight432.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.56mL | 23.12mL |
| 5mM | 0.46mL | 2.31mL | 4.62mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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