BiologicalActivity
Inhibitorofγ-secretase.BlocksNotchcleavage(IC50<2nM)inacell-basedassay;inhibitstheNotchpathway.StimulatestheformationofhumaniPSCsfromhumankeratinocytes.
CompoundLibraries
DBZisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 463.48 |
| Formula | C26H23F2N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 209984-56-5 |
| PubChemID | 11454028 |
| InChIKey | QSHGISMANBKLQL-OWJWWREXSA-N |
| Smiles | CN1C2=C(C=CC=C2)C3=C(C=CC=C3)[C@H](NC([C@@H](NC(CC4=CC(F)=CC(F)=C4)=O)C)=O)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.35 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight463.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.16mL | 10.79mL | 21.58mL |
| 5mM | 0.43mL | 2.16mL | 4.32mL |
| 10mM | 0.22mL | 1.08mL | 2.16mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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