BiologicalActivity
InhibitorofdipeptidylpeptidaseIV(DPP-IV)(IC50=104nM)thatdisplaysselectivityoverenzymeswithDPP-likeactivity(IC50>30μM).IncreasesplasmaGLP-1levelsandimprovesglucosetoleranceindiabeticmicefollowingoralglucosechallenge.
TechnicalData
| M.Wt | 312.8 |
| Formula | C14H20N4O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 866396-70-5 |
| PubChemID | 11381415 |
| InChIKey | RHCWAHDCHQTNBR-IWKKHLOMSA-N |
| Smiles | O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.28 | 100 | |
| ethanol | 7.82 | 25 | |
| water | 15.64 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight312.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.2mL | 15.98mL | 31.97mL |
| 5mM | 0.64mL | 3.2mL | 6.39mL |
| 10mM | 0.32mL | 1.6mL | 3.2mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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