Tocris小分子 Tocris化合物筛选文库,Tocris/DPPI 1c hydrochloride/2783/10/10 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/DPPI 1c hydrochloride/2783/10/10 mg

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Tocris/DPPI 1c hydrochloride/2783/10/10 mg

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Tocris

货号 /

2783/10

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4000-520-616

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Description:DipeptidylpeptidaseIV(DPP-IV)inhibitor

ChemicalName:1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrilehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofdipeptidylpeptidaseIV(DPP-IV)(IC₅₀=104nM)thatdisplaysselectivityoverenzymeswithDPP-likeactivity(IC₅₀>30μM).IncreasesplasmaGLP-1levelsandimprovesglucosetoleranceindiabeticmicefollowingoralglucosechallenge.

TechnicalData

M.Wt	312.8
Formula	C₁₄H₂₀N₄O₂.HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	866396-70-5
PubChemID	11381415
InChIKey	RHCWAHDCHQTNBR-IWKKHLOMSA-N
Smiles	O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	31.28	100
	ethanol	7.82	25
	water	15.64	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight312.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.2mL	15.98mL	31.97mL
5mM	0.64mL	3.2mL	6.39mL
10mM	0.32mL	1.6mL	3.2mL
50mM	0.06mL	0.32mL	0.64mL

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