Tocris报价单 Tocris离子通道调控剂,Tocris/EGCG/4524/50/50 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/EGCG/4524/50/50 mg

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Tocris

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4524/50

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4000-520-616

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Description:β-secretaseinhibitor;inhibitsamyloidassembly

AlternativeNames:Epigallocatechingallate

ChemicalName:3,4,5-Trihydroxybenzoicacid(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-ylester

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

β-secretaseinhibitor(IC₅₀=1.6μM);inhibitsamyloidassembly.InhibitstheformationofamyloidfibrilsbyproteinssuchasAβ,α-synucleinandhuntingtin.ReducesAβ42-inducedcelldeathinthreedifferentcelltypes.Alsoinhibitsglutamatedehydrogenase.InhibitscellgrowthandselectivelyinducesapoptosisinA431andhumanpancreaticcancercells.AlsoaDNMT1inhibitor.

CompoundLibraries

EGCGisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	458.37
Formula	C₂₂H₁₈O₁₁
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	989-51-5
PubChemID	65064
InChIKey	WMBWREPUVVBILR-WIYYLYMNSA-N
Smiles	O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	22.92	50
	ethanol	45.84	100
	water	4.58	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight458.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.18mL	10.91mL	21.82mL
5mM	0.44mL	2.18mL	4.36mL
10mM	0.22mL	1.09mL	2.18mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

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BiologicalActivity

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TechnicalData

SolubilityData

PreparingStockSolutions

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