TocrisX中国代理价格，厂家 Tocris多肽,Tocris/FK 506/3631/10/10 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/FK 506/3631/10/10 mg

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Tocris

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3631/10

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4000-520-616

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Description:Potentcalcineurininhibitor;immunosuppressant

AlternativeNames:Tacrolimus,Fujimycin

ChemicalName:(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentcalcineurin(proteinphosphatase2B)inhibitorthatrequiresFK506-bindingprotein12(FKBP12)foractivity(IC₅₀=3nM).InhibitssecretionofIL-1,IL-2(IC₅₀=1nM),IL-3,IL-4,IL-6(IC₅₀=35nM),GM-CSF,TNFα(IC₅₀=10nM),IFNγandMycfromactivatedTcellsinvitro.Exhibitspotentimmunosuppressive,neuroprotectiveandanticonvulsantactivityinvivo.Analog(ascomycin,Cat.No.4210)alsoavailable.

TechnicalData

M.Wt	804.02
Formula	C₄₄H₆₉NO₁₂
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	104987-11-3
PubChemID	445643
InChIKey	QJJXYPPXXYFBGM-LFZNUXCKSA-N
Smiles	O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	80.4	100
	ethanol	80.4	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight804.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.24mL	6.22mL	12.44mL
5mM	0.25mL	1.24mL	2.49mL
10mM	0.12mL	0.62mL	1.24mL
50mM	0.02mL	0.12mL	0.25mL

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BiologicalActivity

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SolubilityData

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