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Description:Methionineaminopeptidase-2inhibitor;antiangiogenic
ChemicalName:(2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl]2,4,6,8-decatetraenedioicacidester
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antibioticandantiangiogenicagent;covalentlybindsandinhibitsmethionineaminopeptidase-2.Inhibitsendothelialcellproliferationinvitroandtumor-inducedangiogenesisinvivo.Alsoinhibitstumorgrowthinmice.
TechnicalData
| M.Wt | 458.55 |
| Formula | C26H34O7 |
| Storage | Storeat-20°C |
| CASNumber | 23110-15-8 |
| PubChemID | 6917655 |
| InChIKey | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| Smiles | [H][C@@]1([C@]3(C)[C@@H](C/C=C(C)/C)O3)[C@@]2(CO2)CC[C@@H](OC(/C=C/C=C/C=C/C=C/C(O)=O)=O)[C@H]1OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 1.15 | 2.5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight458.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.18mL | 10.9mL | 21.81mL |
| 5mM | 0.44mL | 2.18mL | 4.36mL |
| 10mM | 0.22mL | 1.09mL | 2.18mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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