BiologicalActivity
SelectiveADAM10metalloproteaseinhibitor;displaysover100-foldhigherpotencyatADAM10comparedtoADAM17.BlocksconstitutivereleaseofIL-6R,CX3CL1andCXCL16incell-basedcleavageexperiments.Inhibitscalciumionophore-inducedbetacellulinsheddinginIMPEcells.PreventsE-cadherincleavageinA549cells.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline.
TechnicalData
| M.Wt | 391.5 |
| Formula | C21H33N3O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 260264-93-5 |
| PubChemID | 9952396 |
| InChIKey | GHVMTHKJUAOZJP-CGTJXYLNSA-N |
| Smiles | CNC([C@H]([C@@](C)(C)C)NC([C@H](CCCC1=CC=CC=C1)[C@H](C)N(O)C([H])=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.83 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight391.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.77mL | 25.54mL |
| 5mM | 0.51mL | 2.55mL | 5.11mL |
| 10mM | 0.26mL | 1.28mL | 2.55mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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