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Tocris/GSK 2830371/5140/10/10 mg

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Tocris

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5140/10

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4000-520-616

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Description:PotentandselectiveallostericinhibitorofWip1phosphatase

ChemicalName:5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveallostericinhibitorofWip1phosphatase(IC₅₀=6nM).ExhibitsselectivityforWip1over21otherphosphatases.IncreasesphosphorylationofWip1substrates,includingp53,Chk2,H2AXandATM.Attenuatestumorcellgrowthinavarietyoflymphoidcelllines.Alsoinhibitslymphomaxenograftgrowthinvivo.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesonlyunderagreementfromGlaxoSmithKline

CompoundLibraries

GSK2830371isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	461.02
Formula	C₂₃H₂₉ClN₄O₂S
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1404456-53-6
PubChemID	70983932
InChIKey	IVDUVEGCMXCMSO-FQEVSTJZSA-N
Smiles	ClC1=CC(NCC2=CC=C(C(N[C@H]([C@@](NC4CC4)=O)CC3CCCC3)=O)S2)=C(C)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	46.1	100
	ethanol	23.05	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight461.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.17mL	10.85mL	21.69mL
5mM	0.43mL	2.17mL	4.34mL
10mM	0.22mL	1.08mL	2.17mL
50mM	0.04mL	0.22mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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