BiologicalActivity
Inhibitorofubiquitin-specificprotease(USP)7activity(IC50=424nM).Displaysuncompetitiveinhibition.AlsoinhibitsUSP7-mediatedp53deubiquitination(IC50=0.8μM).StABIlizesp53andinhibitscancercellgrowth;inducesp53-dependentapoptosisinp53wildtypeandnullisogeniccancercelllines.
LicensingInformation
SoldforresearchuseonlyunderpatentlicensefromHybrigenicsS.A.
TechnicalData
| M.Wt | 266.64 |
| Formula | C13H3ClN4O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 924296-39-9 |
| PubChemID | 16065773 |
| InChIKey | BIGPXXAUSQLTQR-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.66 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight266.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.75mL | 18.75mL | 37.5mL |
| 5mM | 0.75mL | 3.75mL | 7.5mL |
| 10mM | 0.38mL | 1.88mL | 3.75mL |
| 50mM | 0.08mL | 0.38mL | 0.75mL |
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