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Description:USP14inhibitor
ChemicalName:1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveinhibitorofUsp14;inhibitsthecatalyticactivityofproteasome-associatedUsp14invitro(IC50<4μM).Stimulatesproteasomeactivityandsubstratedegradation.
CompoundLibraries
IU1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 300.37 |
| Formula | C18H21FN2O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 314245-33-5 |
| PubChemID | 675434 |
| InChIKey | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
| Smiles | O=C(CN2CCCC2)C1=C(C)N(C3=CC=C(F)C=C3)C(C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.04 | 100 | |
| ethanol | 15.02 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight300.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.33mL | 16.65mL | 33.29mL |
| 5mM | 0.67mL | 3.33mL | 6.66mL |
| 10mM | 0.33mL | 1.66mL | 3.33mL |
| 50mM | 0.07mL | 0.33mL | 0.67mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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