BiologicalActivity
Phosphorylationproductofinositol1,4,5-trisphosphate(Ins(1,4,5)P3).PotentinhibitorofIns(1,4,5)P35-phosphatase(IC50~150nM);facilitatesCa2+influxbysensitizingIns(1,4,5)P3-mediatedactivationofICRAC.Athigherconcentrations,actsasaninhibitorofIns(1,4,5)P3 receptors.
TechnicalData
| M.Wt | 804.73 |
| Formula | C6H8O18P4.K8 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 145843-69-2 |
| PubChemID | 16760517 |
| InChIKey | HDLWTQSZUMYYND-QAVKKEKOSA-F |
| Smiles | [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@H]1[C@@H](OP([O-])([O-])=O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight804.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.24mL | 6.21mL | 12.43mL |
| 5mM | 0.25mL | 1.24mL | 2.49mL |
| 10mM | 0.12mL | 0.62mL | 1.24mL |
| 50mM | 0.02mL | 0.12mL | 0.25mL |
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