Tocris产品促销 Tocris GPCR ligands,Tocris/L 006235/3066/10/10 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/L 006235/3066/10/10 mg

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Tocris

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3066/10

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4000-520-616

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Description:PotentcathepsinKinhibitor

ChemicalName:N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,reversIBLecathepsinKinhibitor(IC₅₀=0.25nM)thatdisplays>4000-foldselectivityovercathepsinsB,LandS.Displaysreducedselectivityincell-basedassayspossiblyduetolysosomalaccumulation.Reducescollagenbreakdownandpromotesbonedepositioninvivo.Orallyactiveandhasintrinsicfluorescence.

TechnicalData

M.Wt	466.6
Formula	C₂₄H₃₀N₆O₂S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	294623-49-7
PubChemID	9912381
InChIKey	FIVYCSWOCXEWSE-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2)NC1(CCCCC1)C(NCC#N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	46.66	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight466.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.14mL	10.72mL	21.43mL
5mM	0.43mL	2.14mL	4.29mL
10mM	0.21mL	1.07mL	2.14mL
50mM	0.04mL	0.21mL	0.43mL

ProductDatasheets

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