BiologicalActivity
InhibitorofubiquitinC-terminalhydrolase-L1(UCH-L1)activity(Ki=0.4μM).Causescelldeaththroughtheapoptosispathway;increaseslevelsofhighlyubiquitinatedproteinsanddecreasesubiquitinproteasomeactivity.Activityleadstodramaticalterationsinsynapticproteindistributionandspinemorphologyinvivo.
TechnicalData
| M.Wt | 397.64 |
| Formula | C17H11Cl3N2O3 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 668467-91-2 |
| PubChemID | 24906255 |
| InChIKey | OPQRFPHLZZPCCH-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(CC3=CC(Cl)=CC=C3Cl)C(C2=NOC(C)=O)=O)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.88 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight397.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.51mL | 12.57mL | 25.15mL |
| 5mM | 0.5mL | 2.51mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.51mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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