Tocris离子通道调控剂 TOCRIS 4372-10MG,Tocris/MG 101/3358/5/5 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/MG 101/3358/5/5 mg

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Tocris

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3358/5

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4000-520-616

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Description:Calpaininhibitor;activatesp53-dependentapoptosis

AlternativeNames:Calpaininhibitor-1

ChemicalName:N-Acetyl-L-leucine-L-leucine-L-norleucinal

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Calpaininhibitor(IC₅₀=0.09μM)thatactivatesp53-dependentapoptosisintumorcelllines.Increasesactivatedp53,p21andcaspaselevelsandpromotescellcyclearrestthroughinhibitionofcyclinDdegradationinvitro.Alsoattenuatesischemia/reperfusioninjuryincardiomyocytes,hepatocytesandrenaltubularcellsthroughdownregulationofiNOSandCOX-2expression.

TechnicalData

M.Wt	383.53
Formula	C₂₀H₃₇N₃O₄
Storage	Storeat-20°C
CASNumber	110044-82-1
PubChemID	443118
InChIKey	FMYKJLXRRQTBOR-BZSNNMDCSA-N
Smiles	CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	19.18	50
	ethanol	9.59	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight383.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.61mL	13.04mL	26.07mL
5mM	0.52mL	2.61mL	5.21mL
10mM	0.26mL	1.3mL	2.61mL
50mM	0.05mL	0.26mL	0.52mL

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