Tocris抗体，试剂，血清，细胞美国Tocris Bioscience公司,Tocris/MG 132/1748/5/5 mg,蛋白酶类,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/MG 132/1748/5/5 mg

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Tocris

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1748/5

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4000-520-616

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Description:Proteasomeandcalpaininhibitor.InhibitsNF-κBactivation

AlternativeNames:Z-LLL-al,Z-Leu-Leu-Leu-CHO

ChemicalName:N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentcell-permeableinhibitorofproteasome(IC₅₀=100nM)andcalpain(IC₅₀=1.2μM).InhibitsTNF-α-inducedNF-κBactivationandIκBαdegradation.InducesneuriteoutgrowthinPC12cellsandhasanticancerpropertiesinvitro.

TechnicalData

M.Wt	475.63
Formula	C₂₆H₄₁N₃O₅
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	133407-82-6
PubChemID	90488707
InChIKey	AUQBNOXQYSNYAH-OJSMNCEXSA-N
Smiles	[H]C(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)N[C@@H](CC(C)C)C(C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	47.56	100
	ethanol	47.56	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight475.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.1mL	10.51mL	21.02mL
5mM	0.42mL	2.1mL	4.2mL
10mM	0.21mL	1.05mL	2.1mL
50mM	0.04mL	0.21mL	0.42mL

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